Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.92 |
| ▸ | KDR | P35968 | 2/20 | 0.84 |
| ▸ | AURKA | O14965 | 1/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.84 |
| ▸ | INSR | P06213 | 1/20 | 0.84 |
| ▸ | FBP1 | P09467 | 1/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.84 |
| ▸ | FLT4 | P35916 | 1/20 | 0.84 |
| ▸ | CLK1 | P49759 | 1/20 | 0.84 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.84 |
| ▸ | TEK | Q02763 | 1/20 | 0.84 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529196 | 0.97 | EGFR (0.98) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL30520472 | 0.95 | EGFR (0.87) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13524614 | 0.95 | EGFR (0.87) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL28520911 | 0.94 | EGFR (0.85) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL14964773 | 0.94 | EGFR (0.85) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL30207668 | 0.94 | EGFR (0.85) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL31491085 | 0.94 | EGFR (0.85) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL5911655 | 0.93 | EGFR (0.86) | EGFRKDRAURKAERBB2INSR | |
| Hydrochloric Acid SCHEMBL5911498 | 0.92 | EGFR (0.84) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL9445 | 0.92 | EGFR (0.91) | EGFRKDRAURKAERBB2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163594-A1 | IMMUNOPHILIN BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020163598-A1 | IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |
| US-9617227-B2 | Process of preparing a quinazoline derivative | SCINOPHARM (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2017-04-11 | — | — | US | disclosed |
| US-9546179-B2 | Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof | Qian, Wei (CN) | 2017-01-17 | — | — | US | disclosed |
| US-20160200688-A1 | Process of Preparing a Quinazoline Derivative | SCIANDA (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2016-07-14 | — | — | US | disclosed |
| WO-2015188318-A1 | PROCESS FOR PREPARING QUINAZOLINE DERIVATIVE | SCINOPHARM (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2015-12-17 | — | — | WO | disclosed |
| US-20140206664-A1 | Heterocycle Amido Alkyloxy Substituted Quinazoline Derivative and Use Thereof | QIAN WEI (CN) | 2014-07-24 | — | — | US | disclosed |
| US-7417055-B2 | Kinase inhibitory phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200688-A1 | Process of Preparing a Quinazoline Derivative | ABL1, EGFR, KRAS | EGFR 2/4885KDR 291/4885AURKA 390/4885 |
| US-20140206664-A1 | Heterocycle Amido Alkyloxy Substituted Quinazoline Derivative and Use Thereof | EGFR, ERBB2, ERBB4 | EGFR 1/4885KDR 96/4885AURKA 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.