Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14092468 | 1.00 | NR3C1 (0.56) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL14092478 | 0.88 | NR3C1 (0.56) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL14092474 | 0.88 | NR3C1 (0.56) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL4170200 | 0.85 | NR3C1 (0.79) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL4152743 | 0.85 | NR3C1 (0.79) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL4152738 | 0.85 | NR3C1 (0.79) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL14092469 | 0.85 | NR3C1 (0.62) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL14092470 | 0.85 | NR3C1 (0.62) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL4165853 | 0.84 | NR3C1 (0.81) | NR3C1PGRNR3C2ARCYP19A1 | |
| SCHEMBL4165854 | 0.84 | NR3C1 (0.81) | NR3C1PGRNR3C2ARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |