SCHEMBL140938

SCHEMBL140938

FC(F)(F)c1cc(CCl)cc(C(F)(F)F)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.52
CES2 O00748 1/20 0.41
DAO P14920 2/20 0.40
RHOC P08134 1/20 0.39
RHOA P61586 1/20 0.39
TAAR1 Q96RJ0 1/20 0.38
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
TACR1 P25103 4/20 0.37
MTOR P42345 1/20 0.37
CACNA1F O60840 1/20 0.37
CACNA1D Q01668 1/20 0.37
CACNA1S Q13698 1/20 0.37
CACNA1C Q13936 1/20 0.37
TSHR P16473 1/20 0.37
MLYCD O95822 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17062167 0.86 IDO1 (0.41) IDO1RHOCRHOATACR1TSHR
SCHEMBL1434343 0.86 IDO1 (0.41) IDO1DAOTAAR1RXRARXRB
SCHEMBL25368340 0.84 NOTUM (0.40) IDO1DAORHOCRHOATAAR1
SCHEMBL17703913 0.84 IDO1 (0.39) IDO1CES2DAORHOCRHOA
SCHEMBL3950720 0.80 MRGPRX4 (0.38) IDO1RXRARXRBRXRGTACR1
SCHEMBL265486 0.79 IDO1 (0.52) IDO1CES2DAORXRARXRB
SCHEMBL27789872 0.78 IDO1 (0.35) IDO1TACR1
SCHEMBL5249761 0.78 IDO1 (0.56) IDO1CES2DAOTAAR1RXRA
SCHEMBL2877529 0.77 TSHR (0.50) IDO1TSHR
SCHEMBL29824490 0.77 TAAR1 (0.60) IDO1TAAR1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116661402-B Production control method and system for chemical materials 北京盛世利科技有限公司 2023-10-03 CN claimed
CN-116661402-A Production control method and system for chemical materials 北京盛世利科技有限公司 2023-08-29 CN claimed
EP-1993991-B1 PROCESS FOR THE PREPARATION OF 3,5-BIS (TRIFLUOROMETHYL)-N-METHYLBENZYLAMINE MITENI SPA (IT) 2010-09-22 EP claimed
EP-1993991-A2 PROCESS FOR THE PREPARATION OF 3,5-BIS (TRIFLUOROMETHYL)-N-METHYLBENZYLAMINE MITENI S.p.A. (IT) 2008-11-26 EP claimed
WO-2007107818-A2 PROCESS FOR THE PREPARATION OF 3,5-BIS (TRIFLUOROMETHYL)-N-METHYLBENZYLAMINE MITENI S.P.A. (IT) 2007-09-27 WO claimed
CN-119528810-B Quinoline compound and application thereof 山东第一医科大学(山东省医学科学院) 2025-04-29 CN disclosed
CN-119528810-A Quinoline compound and application thereof 山东第一医科大学(山东省医学科学院) 2025-02-28 CN disclosed
CN-119264124-B Thiazolidinedione compound containing quinoline structure and application thereof 山东第一医科大学(山东省医学科学院) 2025-02-14 CN disclosed
US-12186313-B2 Pyridazinone compounds and their use as DAAO inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-01-07 US disclosed
CN-119264124-A Thiazolidinedione compound containing quinoline structure and application thereof 山东第一医科大学(山东省医学科学院) 2025-01-07 CN disclosed
CN-220370758-U Dampproof device 北京盛世利科技有限公司 2024-01-23 CN disclosed
CN-220370825-U Mixing stirring equipment 北京盛世利科技有限公司 2024-01-23 CN disclosed
US-5578593-A RELEASING GROWTH HORMONES FOR ANIMALS MERCK & CO., INC. (US) 1996-11-26 US disclosed
WO-1996030377-A1 NITROGENOUS MACROCYCLIC COMPOUNDS ISIS PHARMACEUTICALS, INC. (US) 1996-10-03 WO disclosed
EP-0662481-A1 Spiro piperidines and homologs promote release of growth hormone MERCK & CO. INC. (US) 1995-07-12 EP disclosed
WO-1995015311-A1 TACHYKININ ANTAGONISTS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1995-06-08 WO disclosed
WO-1994019367-A1 SPIRO PIPERIDINES AND HOMOLOGS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-09-01 WO disclosed
EP-0009787-B2 PROCESS FOR THE MONOHALOGENATION OF ALKYLBENZENES IN ALPHA POSITION BAYER AG (DE) 1986-07-09 EP disclosed
US-4331821-A ULTRAVIOLET RADIATION OF A VAPORIZED ALKYLBENZEN AND HALOGEN GAS MIXTURE BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed
EP-0009787-A2 Process for the monohalogenation of alkylbenzenes in alpha position BAYER AG (DE) 1980-04-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12186313-B2 Pyridazinone compounds and their use as DAAO inhibitors PNPO, DAO, DPYD IDO1 752/4885CES2 426/4885DAO 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.