Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.33 |
| ▸ | CDC7 | O00311 | 3/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095085 | 0.81 | MEN1 (0.38) | CYP19A1MAPTPDE4BPDE4DLATS1 | |
| SCHEMBL15662341 | 0.76 | CYP19A1 (0.40) | CYP19A1MAPTPDE4BPDE4DKDM4E | |
| SCHEMBL16179473 | 0.70 | PDE4B (0.38) | CYP19A1MAPTPDE4BCDC7DBF4 | |
| SCHEMBL15659115 | 0.68 | PDE4B (0.42) | CYP19A1PDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL27851793 | 0.68 | TNKS2 (0.44) | MAPTPDE4BPDE4DKDM4ENPC1 | |
| SCHEMBL20012206 | 0.66 | MAPT (0.42) | CYP19A1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL980050 | 0.64 | MAPT (0.62) | CYP19A1MAPTLATS1LATS2KDM4E | |
| SCHEMBL21074856 | 0.64 | SMN1; SMN2 (0.33) | MAPTKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL590394 | 0.64 | SMN1; SMN2 (0.37) | ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6543819 | 0.63 | MAPT (0.48) | CYP19A1MAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |