Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | LATS1 | O95835 | 2/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095000 | 0.81 | CYP19A1 (0.34) | RAB9ASMN1; SMN2NPC1MAPTCYP19A1 | |
| SCHEMBL10575968 | 0.77 | PDE4B (0.50) | MEN1KMT2APDE4BPDE4DHTT | |
| SCHEMBL588750 | 0.70 | NPC1 (0.35) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL17476960 | 0.70 | MEN1 (0.38) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL20011841 | 0.69 | MEN1 (0.49) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8491759 | 0.67 | SMN1; SMN2 (0.33) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13176522 | 0.67 | SMN1; SMN2 (0.34) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL19995446 | 0.66 | KMT2A (0.46) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL15662341 | 0.64 | CYP19A1 (0.40) | RAB9ASMN1; SMN2NPC1MAPTCYP19A1 | |
| SCHEMBL16682880 | 0.64 | IDH1 (0.40) | KMT2ARAB9ASMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |