Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HTR5A | P47898 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887585 | 0.82 | HTR5A (0.40) | HDAC3HDAC1HDAC2HTR5AMEN1 | |
| SCHEMBL727320 | 0.78 | HTR2A (0.43) | HDAC3HDAC1HDAC2HTR5AMEN1 | |
| SCHEMBL19114614 | 0.77 | HDAC3 (0.36) | HDAC3HDAC1HDAC2HTR5ACREBBP | |
| SCHEMBL18388633 | 0.77 | HTR5A (0.43) | HDAC3HDAC1HDAC2HTR5AGAA | |
| SCHEMBL25112373 | 0.75 | HTR2C (0.42) | MEN1GAAMAPTALOX15CASP1 | |
| SCHEMBL29238624 | 0.75 | HTR2C (0.42) | MEN1GAAMAPTALOX15CASP1 | |
| SCHEMBL14304542 | 0.75 | HTR2A (0.46) | HDAC3HDAC1HDAC2HTR5AMEN1 | |
| SCHEMBL21391914 | 0.73 | IDO1 (0.57) | HDAC3HDAC1HDAC2EGFR | |
| SCHEMBL21880653 | 0.73 | HDAC3 (0.36) | HDAC3HDAC1HDAC2HTR5AABCB1 | |
| SCHEMBL18271939 | 0.73 | HTR5A (0.41) | HTR5AMEN1GAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429610-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2008-09-30 | — | — | US | disclosed |