Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 6/20 | 0.39 |
| ▸ | CHUK | O15111 | 4/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302665 | 0.89 | IKBKB (0.40) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3302472 | 0.87 | MEN1 (0.45) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3300194 | 0.86 | MEN1 (0.42) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3304044 | 0.84 | RAB9A (0.44) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3301679 | 0.84 | RAB9A (0.43) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3296619 | 0.84 | RAB9A (0.43) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3298134 | 0.84 | MAPT (0.47) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3298093 | 0.84 | MAPT (0.50) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3301666 | 0.83 | TP53 (0.51) | MAPTMEN1KMT2ANPC1LMNA | |
| SCHEMBL3296543 | 0.83 | RAB9A (0.46) | MAPTMEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099073-A1 | N, N' -2, 4-DIANILINOPYRIMIDINES PREPARATION AND USE THEREOF AS IKK INHIBITORS PREPARATION AND TEH PHARMACUETICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |