Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097405 | 0.90 | ABL1 (0.57) | ABL1 | |
| SCHEMBL14097408 | 0.87 | ABL1 (0.39) | ABL1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL14097464 | 0.83 | TUBB4A (0.40) | ABL1 | |
| SCHEMBL14097445 | 0.82 | ABL1 (0.58) | ABL1 | |
| SCHEMBL14097401 | 0.80 | ABL1 (0.61) | ABL1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL14097400 | 0.76 | ABL1 (0.66) | ABL1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL14097749 | 0.75 | BCHE (0.39) | ABL1NPC1RAB9A | |
| SCHEMBL14097422 | 0.75 | ABL1 (0.55) | ABL1 | |
| SCHEMBL14097512 | 0.75 | ABL1 (0.50) | ABL1 | |
| SCHEMBL14097429 | 0.74 | ABL1 (0.59) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |