Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | BUB1 | O43683 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097560 | 0.93 | PDE5A (0.60) | PDE5AADORA3KCNH2 | |
| SCHEMBL14097555 | 0.89 | PDE5A (0.56) | PDE5AADORA3KCNH2 | |
| SCHEMBL14097536 | 0.89 | PDE5A (0.53) | PDE5AADORA3KCNH2BUB1 | |
| SCHEMBL14097565 | 0.88 | PDE5A (0.59) | PDE5AADORA3KCNH2 | |
| SCHEMBL14097568 | 0.88 | PDE5A (0.52) | PDE5AADORA3KCNH2BUB1 | |
| SCHEMBL14097570 | 0.86 | PDE5A (0.55) | PDE5AADORA3KCNH2 | |
| SCHEMBL14097544 | 0.85 | PDE5A (0.58) | PDE5AADORA3KCNH2 | |
| SCHEMBL14097471 | 0.85 | ADORA3 (0.53) | PDE5AADORA3KCNH2BUB1 | |
| SCHEMBL14097558 | 0.84 | PDE5A (0.55) | PDE5AADORA3KCNH2 | |
| SCHEMBL14097537 | 0.84 | PDE5A (0.53) | PDE5AADORA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410973-B2 | 4-amino-substituted pyrimidine derivatives | BAYER HEALTHCARE AG (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7410973-B2 | 4-amino-substituted pyrimidine derivatives | BAYER HEALTHCARE AG (DE) | 2008-08-12 | — | — | US | disclosed |