Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097637 | 0.83 | ABL1 (0.50) | ABL1 | |
| SCHEMBL14097639 | 0.83 | ABL1 (0.46) | ABL1 | |
| SCHEMBL14097621 | 0.83 | ABL1 (0.52) | ABL1 | |
| SCHEMBL14097499 | 0.76 | ABL1 (0.63) | ABL1 | |
| SCHEMBL14097640 | 0.76 | PDE10A (0.45) | ABL1 | |
| SCHEMBL14097547 | 0.75 | ABL1 (0.86) | ABL1 | |
| SCHEMBL1680339 | 0.70 | PRMT5 (0.57) | MEN1KMT2A | |
| SCHEMBL8997571 | 0.69 | ABL1 (0.59) | ABL1 | |
| SCHEMBL12666902 | 0.68 | ABL1 (0.60) | ABL1KMT2A | |
| SCHEMBL14097671 | 0.68 | ABL1 (0.49) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |