Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 14/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097621 | 0.85 | ABL1 (0.52) | ABL1 | |
| SCHEMBL14097642 | 0.82 | ABL1 (0.49) | ABL1 | |
| SCHEMBL14097632 | 0.81 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097639 | 0.80 | ABL1 (0.46) | ABL1 | |
| SCHEMBL14097641 | 0.76 | ABL1 (0.53) | ABL1 | |
| SCHEMBL14097723 | 0.75 | ABL1 (0.48) | ABL1 | |
| SCHEMBL14097427 | 0.74 | PIK3CA (0.52) | ABL1 | |
| SCHEMBL14097625 | 0.74 | ABL1 (0.52) | ABL1 | |
| SCHEMBL19155238 | 0.71 | CTSC (0.55) | PDE10AHRH3 | |
| SCHEMBL14207570 | 0.69 | ABL1 (0.48) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |