Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097654 | 0.90 | KDM4E (0.44) | ABL1 | |
| SCHEMBL14097501 | 0.87 | ABL1 (0.38) | MEN1KMT2AABL1MAPT | |
| SCHEMBL14207569 | 0.84 | CYP2C19 (0.47) | ABL1 | |
| SCHEMBL14097616 | 0.82 | ABL1 (0.48) | ABL1 | |
| SCHEMBL3851404 | 0.80 | ABL1 (0.53) | ABL1 | |
| SCHEMBL14097615 | 0.71 | ABL1 (0.49) | ABL1 | |
| SCHEMBL14097720 | 0.69 | ABL1 (0.57) | ABL1 | |
| SCHEMBL5081749 | 0.69 | ABL1 (0.57) | ABL1 | |
| SCHEMBL14097468 | 0.69 | ABL1 (0.40) | ABL1 | |
| SCHEMBL23071954 | 0.69 | MEN1 (0.65) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |