Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 4/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.38 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494090 | 0.77 | GRIN2D (0.36) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6494093 | 0.77 | GRIN2D (0.36) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL23111410 | 0.73 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL27984863 | 0.73 | PKM (0.47) | NPFFR1NPFFR2MAPT | |
| SCHEMBL4139288 | 0.71 | GRIN2D (0.36) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL891560 | 0.71 | — | — | |
| SCHEMBL9541230 | 0.69 | GRIN2D (0.35) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6026664 | 0.69 | GRIN2D (0.35) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL5306263 | 0.69 | SLC22A2 (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2756 | 0.69 | GRIN2D (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 875 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530234-B2 | CD73 inhibitors and pharmaceutical uses thereof | Risen (Suzhou) Pharma Tech Co., Ltd. (CN) | 2022-12-20 | — | — | US | claimed |
| CN-112759545-B | 3- (dimethylamino methyl) piperidine-4-alcohol derivative and preparation method and pharmaceutical application thereof | 复旦大学 | 2022-12-13 | — | — | CN | claimed |
| EP-3849992-A1 | CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF | Risen (Suzhou) Pharma Tech Co., Ltd. (CN) | 2021-07-21 | — | — | EP | claimed |
| US-20210139526-A1 | CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF | RISEN (SUZHOU) PHARMA TECH Co.,Ltd. (CN) | 2021-05-13 | — | — | US | claimed |
| CN-112771061-A | CD73 inhibitor and pharmaceutical application thereof | 润佳（苏州）医药科技有限公司 | 2021-05-07 | — | — | CN | claimed |
| CN-112759545-A | 3- (dimethylamino methyl) piperidine-4-alcohol derivative and preparation method and pharmaceutical application thereof | 复旦大学 | 2021-05-07 | — | — | CN | claimed |
| US-10881681-B2 | CD73 inhibitors and pharmaceutical uses thereof | Risen (Suzhou) Pharma Tech Co., Ltd. (CN) | 2021-01-05 | — | — | US | claimed |
| WO-2020051686-A1 | CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF | RISEN (SUZHOU) PHARMA TECH CO. LTD. (CN) | 2020-03-19 | — | — | WO | claimed |
| CN-110885352-A | CD73 inhibitor and pharmaceutical application thereof | 润佳（苏州）医药科技有限公司 | 2020-03-17 | — | — | CN | claimed |
| US-20200078388-A1 | CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF | RISEN (SUZHOU) PHARMA TECH CO, LTD. (CN) | 2020-03-12 | — | — | US | claimed |
| EP-0480659-A2 | Use of Angiotensin-II antagonists for the manufacture of a medicament for the treatment of hyperuricemia | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | claimed |
| US-5075339-A | Antiinflammatory agents, antiallergens | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-24 | — | — | US | claimed |
| WO-1991018888-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-12 | — | — | WO | claimed |
| EP-0174956-B1 | SOFT $g(b)-ADRENERGIC BLOCKING AGENTS | BODOR, Nicholas S. (US) | 1990-08-16 | — | — | EP | claimed |
| US-4948813-A | Benzylketone phospholipase A2 inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-08-14 | — | — | US | claimed |
| US-4829086-A | Soft β-adrenergic blocking agents | IVAX International GmbH (CH) | 1989-05-09 | — | — | US | claimed |
| US-4782149-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVES | HOFFMAN-LA ROCHE INC. (US) | 1988-11-01 | — | — | US | claimed |
| US-4757069-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1988-07-12 | — | — | US | claimed |
| EP-0174956-A1 | SOFT -g(b)-ADRENERGIC BLOCKING AGENTS. | BODOR NICHOLAS S | 1986-03-26 | — | — | EP | claimed |
| WO-1985004168-A1 | SOFT beta-ADRENERGIC BLOCKING AGENTS | BODOR NICHOLAS S | 1985-09-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200078388-A1 | CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF | ENTPD5, ENTPD1, NT5E | GRIN2D 4128/4885GRIN3B 2853/4885GRIN1 2629/4885 |
| US-10881681-B2 | CD73 inhibitors and pharmaceutical uses thereof | ENTPD5, ENTPD1, NT5E | GRIN2D 4128/4885GRIN3B 2853/4885GRIN1 2629/4885 |
| US-11530234-B2 | CD73 inhibitors and pharmaceutical uses thereof | ENTPD5, ENTPD1, NT5E | GRIN2D 4128/4885GRIN3B 2853/4885GRIN1 2629/4885 |
| US-20210139526-A1 | CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF | ENTPD5, ENTPD1, NT5E | GRIN2D 4128/4885GRIN3B 2853/4885GRIN1 2629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.