Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312774 | 0.86 | KEAP1 (0.40) | KEAP1NFE2L2L3MBTL1ADRB3CYTH2 | |
| SCHEMBL1474627 | 0.82 | ADRB3 (0.42) | KEAP1NFE2L2L3MBTL1ADRB3CYTH2 | |
| SCHEMBL13685630 | 0.82 | ADRB3 (0.42) | KEAP1NFE2L2L3MBTL1ADRB3CYTH2 | |
| SCHEMBL1285429 | 0.82 | ADRB3 (0.42) | KEAP1NFE2L2L3MBTL1ADRB3CYTH2 | |
| Hydrochloric Acid SCHEMBL1473679 | 0.81 | ADRB3 (0.41) | KEAP1NFE2L2L3MBTL1ADRB3CYTH2 | |
| SCHEMBL24481325 | 0.78 | MAPT (0.41) | KEAP1NFE2L2ADRB3CYTH2KDM4E | |
| SCHEMBL12167639 | 0.78 | AKR1C3 (0.49) | — | |
| SCHEMBL1285577 | 0.78 | TRPV1 (0.35) | KEAP1NFE2L2ADRB3 | |
| SCHEMBL1475960 | 0.78 | TRPV1 (0.35) | KEAP1NFE2L2ADRB3 | |
| SCHEMBL1285578 | 0.78 | TRPV1 (0.35) | KEAP1NFE2L2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824837-B1 | SUBSTITUTED N-SULFONYLAMINOBENZYL-2-PHENOXY ACETAMIDE COMPOUNDS | PFIZER (US) | 2008-08-13 | — | — | EP | disclosed |