Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 4/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263883 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL11578570 | 0.85 | GRM5 (0.43) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL3825817 | 0.85 | GRM5 (0.43) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| Hydrochloric Acid SCHEMBL10559703 | 0.83 | GRM5 (0.42) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL7360763 | 0.83 | PRKCH (0.48) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL2943749 | 0.81 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10CA12 | |
| SCHEMBL4279158 | 0.81 | CYP2C19 (0.54) | ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9977933 | 0.81 | UTS2R (0.48) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL29306393 | 0.80 | TLR8 (0.43) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL6442879 | 0.79 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-20070027158-A1 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
| US-20070027158-A1 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027158-A1 | High affinity small molecule C5a receptor modulators | C3AR1, C5AR1, C5AR2 | ALDH1A1 4042/4885KDM4E 3927/4885HPGD 2949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.