Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 17/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 11/20 | 0.38 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10200557 | 0.85 | CASP1 (0.51) | CASP1CASP8CASP3 | |
| SCHEMBL13139801 | 0.85 | CASP1 (0.51) | CASP1CASP8CASP3 | |
| SCHEMBL646831 | 0.85 | CASP1 (0.51) | CASP1CASP8CASP3 | |
| SCHEMBL645906 | 0.75 | CASP1 (0.65) | CASP1CASP8CASP3 | |
| SCHEMBL13140322 | 0.75 | CASP1 (0.65) | CASP1CASP8CASP3 | |
| SCHEMBL645989 | 0.74 | CASP1 (0.69) | CASP1CASP8CASP3 | |
| SCHEMBL647496 | 0.74 | CASP1 (0.53) | CASP1CASP8CASP3 | |
| SCHEMBL10201769 | 0.74 | CASP1 (0.68) | CASP1CASP8CASP3 | |
| SCHEMBL12444062 | 0.74 | CASP1 (0.68) | CASP1CASP8CASP3 | |
| SCHEMBL10248335 | 0.73 | CASP1 (0.55) | CASP1CASP8CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295442-A2 | Inhibitors of interleukin-1beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-16 | — | — | EP | disclosed |