Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14169252 | 1.00 | CCR2 (0.51) | CCR2CCR5 | |
| SCHEMBL13226230 | 1.00 | CCR2 (0.51) | CCR2CCR5 | |
| SCHEMBL14107362 | 0.89 | CCR2 (0.43) | CCR2CCR5 | |
| SCHEMBL14458770 | 0.86 | CCR2 (0.55) | CCR2CCR5 | |
| SCHEMBL14107346 | 0.85 | CCR2 (0.60) | CCR2CCR5 | |
| SCHEMBL14107344 | 0.85 | CCR2 (0.60) | CCR2CCR5 | |
| SCHEMBL14107345 | 0.85 | CCR2 (0.60) | CCR2CCR5 | |
| SCHEMBL14169275 | 0.82 | CCR2 (0.70) | CCR2 | |
| SCHEMBL14107337 | 0.79 | CCR2 (0.55) | CCR2CCR5 | |
| SCHEMBL14153658 | 0.79 | CCR2 (0.55) | CCR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501803-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |