SCHEMBL14101183

SCHEMBL14101183

O=C1NC(=O)C(c2ccccc2)(C(F)(F)F)N1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.53
CACNA1F O60840 1/20 0.53
ALDH1A1 P00352 1/20 0.53
MAPT P10636 1/20 0.53
HTR2A P28223 1/20 0.53
HRH1 P35367 1/20 0.53
SCN1A P35498 1/20 0.53
SCN4A P35499 1/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
CACNA1D Q01668 1/20 0.53
KCNH2 Q12809 1/20 0.53
CACNA1S Q13698 1/20 0.53
CACNA1C Q13936 1/20 0.53
SCN5A Q14524 1/20 0.53
SCN2A Q99250 1/20 0.53
SCN3A Q9NY46 1/20 0.53
AKR1B1 P15121 1/20 0.45
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL542191 0.81 CYP2C9 (0.53) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL1968442 0.78 TSHR (0.48) AKR1B1MMP2MMP9KDM4E
Phenytoin SCHEMBL1461588 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL3440 0.70 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL5499612 0.70 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL14354280 0.70 CYP2C9 (0.63) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL14581598 0.68 CA1 (0.37) GAACYP3A4
Phenytoin SCHEMBL2905857 0.68 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2140317 0.68 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL10406406 0.68 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7414078-B2 Oral general anesthetics and metabolitically resistant anticonvulsants UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2008-08-19 US disclosed
US-7414078-B2 Oral general anesthetics and metabolitically resistant anticonvulsants UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2008-08-19 US disclosed