Phenytoin

Phenytoin

SCHEMBL3440

O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Phenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A known ✓ P35498 1/20 1.00
SCN4A known ✓ P35499 1/20 1.00
SCN5A known ✓ Q14524 1/20 1.00
SCN2A known ✓ Q99250 1/20 1.00
SCN3A known ✓ Q9NY46 1/20 1.00
CYP2C9 P11712 2/20 1.00
CACNA1F O60840 1/20 1.00
ALDH1A1 P00352 1/20 1.00
MAPT P10636 1/20 1.00
HTR2A P28223 1/20 1.00
HRH1 P35367 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
CACNA1D Q01668 1/20 1.00
KCNH2 Q12809 1/20 1.00
CACNA1S Q13698 1/20 1.00
CACNA1C Q13936 1/20 1.00
AKR1B1 P15121 3/20 0.79
ITGA4 P13612 1/20 0.59
GAA P10253 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenytoin SCHEMBL5499612 1.00 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL28548871 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL157671 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL29521348 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2140317 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL10406406 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL5160618 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2905857 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL1461588 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL6730646 0.98 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 58144 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
US-12640228-B2 Polymorphic markers for pharmacogenetic HLA risk alleles SEMA4 OPCO, INC. (US) 2026-05-26 US claimed
CN-122075410-A Dry powder composition for intranasal delivery 2026-05-26 CN claimed
CN-121558452-B Sample pretreatment method, kit and detection method for anti-epileptic drug detection Lianying Yuezhi Scientific Instrument (Wuhan) Co.,Ltd. (CN) 2026-05-26 CN claimed
US-20260137654-A1 COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER THE REGENTS OF THE UNIV OF CALIFORNIA (US) 2026-05-21 US claimed
US-12629377-B2 Lamotrigine oral liquid suspension and use thereof ROWP IP HOLDING II LLC 2026-05-19 US claimed
CN-117511000-B Anti-adhesion agent and breeding colony house modifier comprising same 成都科宏达科技有限公司 2026-05-15 CN claimed
US-20260124261-A1 STRAIN OF SACCHAROMYCES CEREVISIAE VAR. BOULARDII FOR TREATING INFECTIOUS DISEASES OF THE ORAL CAVITY LESAFFRE ET COMPAGNIE (FR) 2026-05-07 US claimed
US-20260124211-A1 COMPOSITION CONTAINING LAMOTRIGINE, AND PREPARATION METHOD AND USE THEREOF SHANGHAI AUCTA PHARMACEUTICALS CO., LTD. (CN) 2026-05-07 US claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 EP claimed
US-4166767-A Insolubilized antibody DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1979-09-04 US claimed
US-4163058-A ANTICONBULSANTS, ANTIEPLEPTICS, ANTIARRHYTHMICS INTERX RESEARCH CORPORATION (US) 1979-07-31 US claimed
US-4160818-A Fluorimetric immunoassay for diphenylhydantoin TECHNICON INSTRUMENTS CORPORATION (US) 1979-07-10 US claimed
US-4145407-A LABELED 5,5-DIPHENYLHYDANTOIN DERIVATIVES FOR RADIOIMMUNOASSAY BAXTER TRAVENOL LABORATORIES, INC. (US) 1979-03-20 US claimed
US-4113490-A DEVELOPMENT, AMPLIFYING BATH CONTAINING HYDROGEN PEROXIDE KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1978-09-12 US claimed
US-4110461-A EFFECT OF DIPHENYLHYDANTOIN AND RELATED COMPOUNDS ON GLAUCOMA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1978-08-29 US claimed
US-4104029-A CHEMILUMINESCENT LABELING MAIER JR CHARLES L 1978-08-01 US claimed
US-4094682-A Method for processing light-sensitive silver halide photographic material KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) 1978-06-13 US claimed
US-4036227-A Osmotic releasing device having a plurality of release rate patterns ALZA CORPORATION (US) 1977-07-19 US claimed
US-3962430-A Sterilization of solid non-electrolyte medicinal agents employing sodium chloride MERCK & CO., INC. (US) 1976-06-08 US claimed