Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12736938 | 1.00 | POLB (0.50) | POLBNPSR1MAPTTHRBPIN1 | |
| SCHEMBL13481194 | 0.88 | LMNA (0.45) | POLBNPSR1ALDH1A1KMT2ALMNA | |
| SCHEMBL13481195 | 0.88 | LMNA (0.45) | POLBNPSR1ALDH1A1KMT2ALMNA | |
| SCHEMBL31078910 | 0.85 | LMNA (0.45) | POLBNPSR1MAPTALDH1A1HTT | |
| SCHEMBL8171410 | 0.83 | KCNN4 (0.56) | POLBMAPTTHRBALDH1A1KMT2A | |
| SCHEMBL27910386 | 0.83 | KCNN4 (0.47) | POLBMAPTTHRBALDH1A1KMT2A | |
| SCHEMBL23396954 | 0.82 | POLB (0.46) | POLBNPSR1MAPTTHRBPIN1 | |
| SCHEMBL3253069 | 0.82 | KMT2A (0.50) | POLBNPSR1MAPTTHRBPIN1 | |
| SCHEMBL10716883 | 0.82 | MAPT (0.40) | POLBNPSR1MAPTTHRBPIN1 | |
| SCHEMBL236357 | 0.81 | CES1 (0.47) | MAPTALDH1A1KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716145-B1 | DIHYDROTETRABENAZINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CAMBRIDGE LAB IRELAND LTD (IE) | 2008-08-27 | — | — | EP | disclosed |