Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.60 |
| ▸ | BCHE | P06276 | 6/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410316 | 1.00 | HDAC8 (0.60) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1411306 | 0.85 | HDAC1 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1411300 | 0.85 | HDAC1 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1410552 | 0.83 | HDAC1 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1411340 | 0.83 | HDAC1 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1410554 | 0.83 | HDAC1 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1411342 | 0.83 | HDAC1 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL726133 | 0.80 | HDAC8 (0.72) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL726134 | 0.80 | HDAC8 (0.72) | HDAC8HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL19712557 | 0.76 | HDAC8 (0.51) | HDAC8HDAC3HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |