Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410552 | 1.00 | HDAC1 (0.54) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1411342 | 1.00 | HDAC1 (0.54) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1411340 | 1.00 | HDAC1 (0.54) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1410813 | 0.90 | HDAC4 (0.55) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1410811 | 0.90 | HDAC4 (0.55) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1411159 | 0.87 | HDAC1 (0.44) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1411157 | 0.87 | HDAC1 (0.44) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1410318 | 0.83 | HDAC8 (0.60) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1410316 | 0.83 | HDAC8 (0.60) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL1410833 | 0.82 | HDAC1 (0.61) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |