Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 6/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14103743 | 0.84 | PRKCI (0.40) | PRKCICSNK2A1NPC1RAB9ANPSR1 | |
| SCHEMBL14103741 | 0.79 | MAPT (0.49) | PRKCINPC1RAB9ANPSR1CTDSP1 | |
| SCHEMBL14975058 | 0.79 | PRKCI (0.57) | PRKCI | |
| SCHEMBL14104415 | 0.77 | PIK3CA (0.46) | CSNK2A1MAPTKMT2A | |
| SCHEMBL14975290 | 0.76 | PRKCI (0.39) | PRKCINPC1RAB9ANPSR1CTDSP1 | |
| SCHEMBL14104151 | 0.75 | PIK3CA (0.39) | CSNK2A1NPC1RAB9ANPSR1CTDSP1 | |
| SCHEMBL13789442 | 0.72 | AXL (0.39) | PRKCICSNK2A1NPC1RAB9ANPSR1 | |
| SCHEMBL13789321 | 0.72 | AXL (0.39) | PRKCICSNK2A1NPC1RAB9ANPSR1 | |
| SCHEMBL14975194 | 0.72 | PRKCI (0.39) | PRKCI | |
| SCHEMBL14103783 | 0.72 | CSNK2A1 (0.40) | CSNK2A1NPC1RAB9ANPSR1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |