Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104146 | 0.90 | AXL (0.40) | CSNK2A1AXLMKNK1MKNK2MAPT | |
| SCHEMBL13789439 | 0.88 | AXL (0.39) | CSNK2A1AXLMKNK1MKNK2ABL1 | |
| SCHEMBL14103783 | 0.87 | CSNK2A1 (0.40) | CSNK2A1TSPOABCG2ABL1MAPT | |
| SCHEMBL13789440 | 0.82 | AXL (0.41) | AXLMKNK1MKNK2MAPTNPC1 | |
| SCHEMBL13789312 | 0.82 | AXL (0.41) | AXLMKNK1MKNK2MAPTNPC1 | |
| SCHEMBL13789316 | 0.81 | MAPT (0.50) | AXLMKNK1MKNK2MAPTNPC1 | |
| SCHEMBL13789313 | 0.81 | AXL (0.46) | AXLMKNK1MKNK2CASP3NPC1 | |
| SCHEMBL14104075 | 0.80 | CYP1A2 (0.40) | CSNK2A1TSPOABCG2MAPTHTT | |
| SCHEMBL14103871 | 0.79 | PIK3CA (0.42) | CSNK2A1AXLMKNK1MKNK2ABCG2 | |
| SCHEMBL4518564 | 0.79 | AXL (0.39) | CSNK2A1AXLMKNK1MKNK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |