Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11480056 | 0.85 | HDAC8 (0.73) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL14875220 | 0.82 | HDAC8 (0.70) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL14875223 | 0.82 | HDAC8 (0.70) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL5598861 | 0.82 | HDAC8 (0.69) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL3007219 | 0.82 | HDAC8 (0.69) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL5433891 | 0.81 | HDAC8 (0.68) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL30071536 | 0.81 | HDAC8 (0.68) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL23069115 | 0.80 | HDAC8 (0.67) | HDAC8HDAC6PLK1MTNR1AMTNR1B | |
| SCHEMBL2903467 | 0.80 | HDAC8 (0.67) | HDAC8HDAC6HDAC1PLK1MTNR1A | |
| SCHEMBL600540 | 0.80 | HDAC8 (0.67) | HDAC8HDAC6HDAC1PLK1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180051314-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-22 | — | — | US | disclosed |
| US-20180051314-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-22 | — | — | US | disclosed |
| US-9745613-B2 | Compounds, substrates and methods related to histone deacetylases | THE BROAD INSTITUTE, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745613-B2 | Compounds, substrates and methods related to histone deacetylases | THE BROAD INSTITUTE, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-03 | — | — | US | disclosed |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-03 | — | — | US | disclosed |
| WO-2008101186-A1 | INHIBITORS FOR HDAC8 | THE J. DAVID GLADSTONE INSTITUTES (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051314-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | HDAC1, HDAC11, HDAC10 | HDAC8 18/4885HDAC6 16/4885HDAC1 1/4885 |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | HDAC1, HDAC11, HDAC10 | HDAC8 20/4885HDAC6 18/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.