Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14109213 | 0.92 | MAPK14 (0.62) | MAPK14MLNRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6494994 | 0.92 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19CHRM2 | |
| SCHEMBL14109146 | 0.90 | MAPK14 (0.54) | MAPK14MLNRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14109436 | 0.89 | MAPK14 (0.58) | MAPK14CYP2C9CYP2C19CHRM2 | |
| SCHEMBL14109295 | 0.87 | MAPK14 (0.58) | MAPK14CYP2C9CYP2C19CHRM2 | |
| SCHEMBL14109144 | 0.87 | MAPK14 (0.71) | MAPK14CYP2C9CYP2C19CHRM2 | |
| SCHEMBL14109439 | 0.85 | MAPK14 (0.62) | MAPK14CYP2C9CYP2C19CHRM2 | |
| SCHEMBL14109493 | 0.85 | MAPK14 (0.48) | MAPK14MLNRCYP3A4 | |
| SCHEMBL4509301 | 0.85 | MAPK14 (0.54) | MAPK14MLNRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13936103 | 0.85 | MAPK14 (0.54) | MAPK14MLNRCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393851-B2 | Azaindole derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7393851-B2 | Azaindole derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7244441-B2 | Stents and intra-luminal prostheses containing map kinase inhibitors | SCIOS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244441-B2 | Stents and intra-luminal prostheses containing map kinase inhibitors | SCIOS, INC. (US) | 2007-07-17 | — | — | US | disclosed |