Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936103 | 1.00 | MAPK14 (0.54) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL4512494 | 0.91 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL4500993 | 0.86 | MAPK14 (0.71) | MAPK14CYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL14109166 | 0.85 | MAPK14 (0.54) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL13936100 | 0.83 | MAPK14 (0.76) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL4505691 | 0.83 | MAPK14 (0.76) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL5201020 | 0.82 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL5204726 | 0.80 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL14454067 | 0.80 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19MLNRCYP3A4 | |
| SCHEMBL5203992 | 0.80 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488744-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-20070232617-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| US-7220763-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20040142940-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142940-A1 | Indole-type derivatives as inhibitors of p38 kinase | MAPK1, MAPKAPK2, MAPK4 | MAPK14 28/4885CYP2C9 3358/4885CYP2C19 2876/4885 |
| US-20070232617-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | MAPK1, MAPKAPK2, MAPKAPK5 | MAPK14 38/4885CYP2C9 3723/4885CYP2C19 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.