Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14110249 | 0.84 | IGF1R (0.46) | GRM4MEN1KMT2AEGFRIGF1R | |
| SCHEMBL13301176 | 0.83 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL17888756 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL13301192 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL13301187 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL5443952 | 0.81 | GRM4 (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL17888771 | 0.80 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL13301185 | 0.80 | TERT (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| Puquitinib SCHEMBL14110230 | 0.80 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL13301171 | 0.80 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897882-B1 | N2-QUINOLYL OR ISOQUINOLYL SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | ZHE JIANG MEDECINE CO LTD XINCHANG PHARMACEUTICAL FACTORY (CN) | 2014-12-10 | — | — | EP | disclosed |
| US-7399754-B2 | N2-quinoline or isoquinoline substituted purine derivatives | ZHEJIANG MEDICINE CO., LTD. (CN) | 2008-07-15 | — | — | US | disclosed |
| US-7399754-B2 | N2-quinoline or isoquinoline substituted purine derivatives | ZHEJIANG MEDICINE CO., LTD. (CN) | 2008-07-15 | — | — | US | disclosed |
| EP-1897882-A1 | N2-QUINOLYL OR ISOQUINOLYL SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | Zhe Jiang Medecine Co., Ltd. Xinchang Pharmaceutical Factory (CN) | 2008-03-12 | — | — | EP | disclosed |