Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735749 | 0.83 | OPRM1 (0.41) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL734697 | 0.77 | OPRM1 (0.45) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL733672 | 0.73 | OPRM1 (0.40) | HTR2AHTR2CDRD2OPRM1OPRL1 | |
| SCHEMBL734951 | 0.72 | KDM4E (0.43) | OPRM1OPRL1OGFRL1KDM4E | |
| SCHEMBL735943 | 0.70 | OPRM1 (0.36) | HTR2AHTR2COPRM1OPRL1SIGMAR1 | |
| SCHEMBL735790 | 0.68 | OPRM1 (0.41) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL734685 | 0.68 | OPRM1 (0.41) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL736060 | 0.68 | OPRM1 (0.48) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL735200 | 0.67 | HTR2A (0.51) | HTR2AHTR2CDRD2OPRM1OPRL1 | |
| SCHEMBL734919 | 0.67 | HTR2A (0.52) | HTR2AHTR2CDRD2OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |