Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 16/20 | 0.49 |
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734825 | 0.85 | OPRM1 (0.50) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL3939681 | 0.85 | OPRM1 (0.49) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL735389 | 0.84 | OPRM1 (0.48) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL735959 | 0.83 | OPRM1 (0.47) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL733990 | 0.83 | OPRM1 (0.47) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL3930717 | 0.83 | OPRM1 (0.47) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL736432 | 0.83 | OPRM1 (0.47) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL14110505 | 0.83 | OPRM1 (0.49) | OPRM1OPRL1OGFRL1OPRD1OPRK1 | |
| SCHEMBL14110496 | 0.82 | KDM4E (0.48) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL3932682 | 0.81 | OPRM1 (0.48) | OPRM1OPRL1OGFRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | claimed |