Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | CDK8 | P49336 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658024 | 0.90 | IKBKB (0.74) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL13979607 | 0.86 | IKBKB (0.55) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL14110788 | 0.85 | IKBKB (0.80) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL14110797 | 0.83 | IKBKB (0.81) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL14110777 | 0.81 | IKBKB (0.81) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL14110798 | 0.79 | IKBKB (0.59) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL5649173 | 0.77 | IKBKB (0.56) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL13979558 | 0.77 | IKBKB (0.59) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL14110689 | 0.75 | IKBKB (0.55) | IKBKBLIMK1ALDH1A1KDM4ECDK8 | |
| SCHEMBL12562445 | 0.74 | ALDH1A1 (0.80) | IKBKBLIMK1ALDH1A1KDM4ECDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405225-B2 | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |