Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 14/20 | 0.79 |
| ▸ | CDK19 | Q9BWU1 | 7/20 | 0.62 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14110692 | 0.99 | CDK8 (0.77) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL14110794 | 0.90 | CDK8 (0.64) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL14110785 | 0.89 | CDK8 (0.64) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4656716 | 0.88 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL16071213 | 0.88 | CDK8 (0.81) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5236246 | 0.88 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5234827 | 0.88 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL14110671 | 0.88 | CDK8 (0.61) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4657878 | 0.87 | CDK8 (0.97) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL16071234 | 0.87 | CDK8 (0.79) | CDK8CDK19RIOK2CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405225-B2 | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |