Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 14/20 | 1.00 |
| ▸ | CDK19 | Q9BWU1 | 7/20 | 0.77 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.67 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.67 |
| ▸ | GSK3A | P49840 | 1/20 | 0.67 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.67 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656716 | 1.00 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5234827 | 1.00 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4657878 | 0.99 | CDK8 (0.97) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL16071213 | 0.90 | CDK8 (0.81) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5229194 | 0.89 | CDK8 (0.80) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4659097 | 0.89 | CDK8 (0.79) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL14110686 | 0.88 | CDK8 (0.79) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4659310 | 0.88 | CDK8 (0.79) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5229515 | 0.88 | CDK8 (0.79) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5234204 | 0.88 | CDK8 (0.78) | CDK8CDK19RIOK2CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219234-A1 | Thienopyridine Derivatives | SANKYO COMPANY, LIMITED (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1764367-A1 | THIENOPYRIDINE DERIVATIVES | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219234-A1 | Thienopyridine Derivatives | RASGRP1, NRAS, HRH3 | CDK8 2017/4885CDK19 1842/4885RIOK2 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.