Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411072 | 1.00 | KDM4E (0.50) | KDM4EL3MBTL1TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL1969309 | 0.80 | KDM4E (0.41) | KDM4EL3MBTL1TBXAS1MEN1LMNA | |
| SCHEMBL1704854 | 0.80 | TBXAS1 (0.49) | KDM4EL3MBTL1TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL1914364 | 0.80 | KDM4E (0.42) | KDM4EL3MBTL1TBXAS1ALDH1A1MEN1 | |
| SCHEMBL15755442 | 0.80 | TBXAS1 (0.49) | KDM4EL3MBTL1TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL16737458 | 0.80 | KDM4E (0.42) | KDM4EL3MBTL1TBXAS1ALDH1A1MEN1 | |
| SCHEMBL2959588 | 0.76 | TBXAS1 (0.57) | TBXAS1CYP3A4CYP2C9PSEN1PSEN2 | |
| SCHEMBL11120260 | 0.73 | TDP1 (0.50) | KDM4EL3MBTL1TBXAS1ALDH1A1MEN1 | |
| SCHEMBL1410986 | 0.72 | EGFR (0.50) | KDM4EL3MBTL1TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL1410982 | 0.72 | EGFR (0.50) | KDM4EL3MBTL1TBXAS1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |