Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.50 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411293 | 1.00 | HDAC1 (0.55) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1410770 | 0.84 | HDAC1 (0.58) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1410766 | 0.84 | HDAC1 (0.58) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1410811 | 0.81 | HDAC4 (0.55) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1410813 | 0.81 | HDAC4 (0.55) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1411154 | 0.80 | HDAC1 (0.56) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1411155 | 0.80 | HDAC1 (0.56) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1410552 | 0.76 | HDAC1 (0.54) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1410554 | 0.76 | HDAC1 (0.54) | HDAC1HDAC3HDAC4HDAC8HDAC6 | |
| SCHEMBL1411342 | 0.76 | HDAC1 (0.54) | HDAC1HDAC3HDAC4HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |