Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14115800 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL3735455 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL3735450 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL5293356 | 0.80 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL5293348 | 0.80 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL3611594 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL3611598 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL1055352 | 0.78 | HCAR2 (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2P4HTM | |
| SCHEMBL1055350 | 0.78 | HCAR2 (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2P4HTM | |
| SCHEMBL27688186 | 0.78 | HCAR2 (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496905-B1 | MODULATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | UNIV JOHNS HOPKINS MED (US) | 2008-08-13 | — | — | EP | disclosed |