Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.86 |
| ▸ | ESR1 | P03372 | 1/20 | 0.86 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.86 |
| ▸ | MMP3 | P08254 | 1/20 | 0.86 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.86 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.86 |
| ▸ | LOX | P28300 | 1/20 | 0.86 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.86 |
| ▸ | RAB9A | P51151 | 1/20 | 0.86 |
| ▸ | GFER | P55789 | 1/20 | 0.86 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.86 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.86 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144753 | 0.95 | — | — | |
| SCHEMBL435760 | 0.95 | ESR1 (0.95) | ESR1HSP90AA1MMP3CHRM1TBXA2R | |
| SCHEMBL726811 | 0.95 | — | — | |
| SCHEMBL19900041 | 0.93 | ESR1 (0.90) | ESR1HSP90AA1MMP3CHRM1TBXA2R | |
| SCHEMBL7054726 | 0.93 | ESR1 (0.90) | ESR1HSP90AA1MMP3CHRM1TBXA2R | |
| SCHEMBL8333927 | 0.93 | ESR1 (0.90) | ESR1HSP90AA1MMP3CHRM1TBXA2R | |
| SCHEMBL2427022 | 0.93 | ESR1 (1.00) | ESR1HSP90AA1MMP3CHRM1TBXA2R | |
| SCHEMBL24755 | 0.93 | — | — | |
| SCHEMBL1250766 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL11149339 | 0.90 | ESR1 (0.95) | ESR1HSP90AA1MMP3CHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9446009-B2 | Methods for treating conditions of the nail unit | HALLUX, INC. (US) | 2016-09-20 | — | — | US | claimed |
| US-20140322293-A1 | METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | HALLUX, INC. (US) | 2014-10-30 | — | — | US | claimed |
| US-8747820-B2 | Methods for treating conditions of the nail unit | HALLUX, INC. (US) | 2014-06-10 | — | — | US | claimed |
| US-20140050772-A1 | METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | Hallux. Inc. (US) | 2014-02-20 | — | — | US | claimed |
| US-8591870-B2 | Compositions and methods for treating conditions of the nail unit | HALLUX, INC. (US) | 2013-11-26 | — | — | US | claimed |
| US-8354095-B2 | biodegradable drug delivery system; fungal infection; inflammation; injection | HALLUX, INC. (US) | 2013-01-15 | — | — | US | claimed |
| US-20110104235-A1 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | TALIMA (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC | 2011-05-05 | — | — | US | claimed |
| EP-2295036-A2 | Liquid compositions and methods for treating conditions of the nail unit | Talima Therapeutics, Inc. (US) | 2011-03-16 | — | — | EP | claimed |
| EP-2037880-A2 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | Talima Therapeutics, Inc. (US) | 2009-03-25 | — | — | EP | claimed |
| US-20080132442-A1 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | TALIMA (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC | 2008-06-05 | — | — | US | claimed |
| WO-2007139804-A2 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | TALIMA THERAPEUTICS, INC. (US) | 2007-12-06 | — | — | WO | claimed |
| EP-1827401-A2 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | Talima Therapeutics, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| US-20060275230-A1 | Compositions and methods for treating conditions of the nail unit | TALIMA THERAPEUTICS, INC. | 2006-12-07 | — | — | US | claimed |
| US-20060153786-A1 | Compositions and methods for treating conditions of the nail unit | TALIMA THERAPEUTICS, INC. (US) | 2006-07-13 | — | — | US | claimed |
| WO-2006063350-A2 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT | TALIMA THERAPEUTICS, INC. (US) | 2006-06-15 | — | — | WO | claimed |
| US-11524051-B2 | Methods of treating fungal infections | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2022-12-13 | — | — | US | disclosed |
| US-10946065-B2 | Methods of treating fungal infections | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2021-03-16 | — | — | US | disclosed |
| US-6846837-B2 | Topical administration of basic antifungal compositions to treat fungal infections of the nails | TECHNOLOGY RECOVERY SYSTEMS, LLC | 2005-01-25 | — | — | US | disclosed |
| WO-2004000291-A1 | TOPICAL ADMINISTRATION OF BASIC ANTIFUNGAL COMPOSITIONS TO TREAT FUNGAL INFECTIONS OF THE NAILS | DERMATRENDS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |
| US-20030235541-A1 | Topical administration of basic antifungal compositions to treat fungal infections of the nails | TECHNOLOGY RECOVERY SYSTEMS, LLC | 2003-12-25 | — | — | US | disclosed |