Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.84 |
| ▸ | TP53 | P04637 | 11/20 | 0.83 |
| ▸ | MAPT | P10636 | 7/20 | 0.83 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 4/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412477 | 0.90 | TP53 (0.85) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412216 | 0.88 | TP53 (0.81) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412346 | 0.88 | MAPT (0.84) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412319 | 0.88 | TP53 (0.81) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412316 | 0.88 | TP53 (0.85) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL13603573 | 0.88 | TP53 (0.81) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412344 | 0.87 | SMN1; SMN2 (0.80) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412391 | 0.86 | TP53 (0.75) | THRBTP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1412470 | 0.86 | THRB (0.88) | THRBTP53MAPTRXFP1LMNA | |
| SCHEMBL1412278 | 0.85 | TP53 (0.78) | THRBTP53MAPTRXFP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2015-07-23 | — | — | US | claimed |
| US-9029376-B2 | Small molecule inhibitors for the treatment or prevention of dengue virus infection | SIGA TECHNOLOGIES, INC. (US) | 2015-05-12 | — | — | US | claimed |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2011-06-30 | — | — | US | claimed |
| EP-2293671-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | Siga Technologies, Inc. (US) | 2011-03-16 | — | — | EP | claimed |
| WO-2009149054-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. (US) | 2009-12-10 | — | — | WO | claimed |
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2015-07-23 | — | — | US | disclosed |
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2015-07-23 | — | — | US | disclosed |
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2015-07-23 | — | — | US | disclosed |
| US-9029376-B2 | Small molecule inhibitors for the treatment or prevention of dengue virus infection | SIGA TECHNOLOGIES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029376-B2 | Small molecule inhibitors for the treatment or prevention of dengue virus infection | SIGA TECHNOLOGIES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029376-B2 | Small molecule inhibitors for the treatment or prevention of dengue virus infection | SIGA TECHNOLOGIES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2011-06-30 | — | — | US | disclosed |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2011-06-30 | — | — | US | disclosed |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. | 2011-06-30 | — | — | US | disclosed |
| EP-2293671-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | Siga Technologies, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |
| WO-2009149054-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009149054-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SIGA TECHNOLOGIES, INC. (US) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150202195-A1 | SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | SNRPE, EIF2AK2, HAVCR2 | THRB 2924/4885TP53 2666/4885MAPT 219/4885 |
| US-20110158940-A1 | SAMLL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION | HAVCR2, HNRNPLL, SAMSN1 | THRB 2882/4885TP53 2801/4885MAPT 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.