Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 2/20 | 0.44 |
| ▸ | COMT | P21964 | 2/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13555553 | 0.86 | BRD4 (0.44) | GSTP1COMTNPC1CYP1A2CYP2C19 | |
| SCHEMBL9652539 | 0.85 | MAPK14 (0.49) | GSTP1COMTMEN1KMT2ANPC1 | |
| SCHEMBL14124826 | 0.85 | GSTP1 (0.41) | GSTP1COMTALPGPTK2BMEN1 | |
| SCHEMBL28507869 | 0.83 | COMT (0.45) | GSTP1COMTALPGPTK2BMEN1 | |
| SCHEMBL28501968 | 0.83 | COMT (0.45) | GSTP1COMTNPC1CYP1A2CYP2C19 | |
| SCHEMBL20541074 | 0.83 | COMT (0.51) | GSTP1COMTMEN1KMT2AMAPK14 | |
| SCHEMBL9171508 | 0.83 | FFAR1 (0.44) | FFAR1NPC1CYP1A2CYP2C19RECQL | |
| SCHEMBL28506693 | 0.82 | COMT (0.56) | GSTP1COMTMAPK14 | |
| SCHEMBL20540920 | 0.81 | COMT (0.49) | GSTP1COMTMAPK14 | |
| SCHEMBL28499829 | 0.81 | COMT (0.49) | GSTP1COMTNPC1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | GSTP1 2892/4885COMT 1386/4885ALPG 4719/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | GSTP1 2892/4885COMT 1386/4885ALPG 4719/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | GSTP1 2892/4885COMT 1386/4885ALPG 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.