Argadin

Argadin

SCHEMBL141316

CC(=O)N/C(N)=N/CCC[C@@H]1NC(=O)[C@H](CCCC(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)N2C(=O)[C@H](C[C@H]2O)NC(=O)[C@H]2CCCN2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.44
ITGAV P06756 1/20 0.40
ITGB8 P26012 1/20 0.40
MC1R Q01726 8/20 0.39
MC4R P32245 6/20 0.39
MC5R P33032 6/20 0.39
MC3R P41968 6/20 0.39
MEN1 O00255 2/20 0.39
HRH2 P25021 1/20 0.39
HRH1 P35367 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
PLAU P00749 1/20 0.38
SLC40A1 Q9NP59 3/20 0.38
FLT1 P17948 1/20 0.38
KLKB1 P03952 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4316809 0.66 SMN1; SMN2 (1.00) SMN1; SMN2HRH4HRH3
SCHEMBL4316806 0.66 SMN1; SMN2 (1.00) SMN1; SMN2HRH4HRH3
SCHEMBL12228287 0.66 SMN1; SMN2 (1.00) SMN1; SMN2HRH4HRH3
SCHEMBL22096056 0.66 SMN1; SMN2 (1.00) SMN1; SMN2HRH4HRH3
Livoletide SCHEMBL29373826 0.65 PCSK9 (0.58) SMN1; SMN2KLKB1
SCHEMBL4309179 0.64 F2 (0.60) MEN1
SCHEMBL30254635 0.63 PLAU (0.50) SMN1; SMN2ITGAVMEN1PLAUSLC40A1
SCHEMBL30940074 0.62 HDAC4 (0.54)
SCHEMBL14952768 0.61 HDAC4 (0.56) SMN1; SMN2
SCHEMBL14952812 0.58 HDAC4 (0.55) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140141031-A1 PATHOGENIC BACTERIA ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE (GB) 2014-05-22 US claimed
EP-2710028-A1 PATHOGENIC BACTERIA Royal Holloway And Bedford New College (GB) 2014-03-26 EP claimed
WO-2012160345-A1 PATHOGENIC BACTERIA ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE (GB) 2012-11-29 WO claimed
WO-2004092404-A2 INHIBITORS OF ACIDIC MAMMALIAN CHITINASE AS ASTHMA THERAPEUTICS WYETH (US) 2004-10-28 WO claimed
CN-116425696-B Oxadiazole nitrobenzguanylurea compound and preparation method and application thereof 中国农业大学 2025-03-07 CN disclosed
US-20250051830-A1 MEMBRANE-EMBEDDED NANOPORE AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2025-02-13 US disclosed
CN-117924146-A Indole methyl guanidyl urea compound and preparation method and application thereof 中国农业大学 2024-04-26 CN disclosed
CN-115636773-B Aryl ester compound containing guanylurea or guanylester, and preparation and application thereof 中国农业大学 2023-11-17 CN disclosed
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
CN-116444421-A Arylpiperidine compound containing guanidyl urea and preparation and application thereof 中国农业大学 2023-07-18 CN disclosed
CN-116425696-A Oxadiazole nitrobenzguanylurea compound and preparation method and application thereof 中国农业大学 2023-07-14 CN disclosed
WO-2023064805-A1 MEMBRANE-EMBEDDED NANOPORE AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2023-04-20 WO disclosed
EP-1951868-A2 INTEGRATION OF SAMPLE STORAGE AND SAMPLE MANAGEMENT FOR LIFE SCIENCE Biomatrica, Inc. (US) 2008-08-06 EP disclosed
US-20080176209-A1 INTEGRATION OF SAMPLE STORAGE AND SAMPLE MANAGEMENT FOR LIFE SCIENCE BIOMATRICA, INC. (US) 2008-07-24 US disclosed
EP-1893614-A1 INHIBITOR COMPOUNDS The University Court of the University of Dundee (GB) 2008-03-05 EP disclosed
WO-2007098033-A2 FEEDBACK PRODRUG UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC . (US) 2007-08-30 WO disclosed
WO-2007075253-A2 INTEGRATION OF SAMPLE STORAGE AND SAMPLE MANAGEMENT FOR LIFE SCIENCE BIOMATRICA, INC. (US) 2007-07-05 WO disclosed
WO-2006136822-A1 INHIBITOR COMPOUNDS UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) 2006-12-28 WO disclosed
US-20060099567-A1 Desolventizing, dehydration, dryness; for automated storing, tracking retrieving and analyzing of nucleic acid samples; refrigeration-free BIOMATRICA, INC. (US) 2006-05-11 US disclosed
WO-2004092404-A2 INHIBITORS OF ACIDIC MAMMALIAN CHITINASE AS ASTHMA THERAPEUTICS WYETH (US) 2004-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060099567-A1 Desolventizing, dehydration, dryness; for automated storing, tracking retrieving and analyzing of nucleic acid samples; refrigeration-free DNASE1, DCTD, DNASE1L3 SMN1; SMN2 2055/4885ITGAV 2166/4885ITGB8 2507/4885
US-20080176209-A1 INTEGRATION OF SAMPLE STORAGE AND SAMPLE MANAGEMENT FOR LIFE SCIENCE NEFM, DNASE1, DCTD SMN1; SMN2 359/4885ITGAV 1731/4885ITGB8 1853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.