DNASE1L3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6037129	1.00	1/20
SCHEMBL60351	0.80	1/20
SCHEMBL60352	0.80	1/20
SCHEMBL70833	0.76	1/20
SCHEMBL71580	0.73	1/20
SCHEMBL4435888	0.70	1/20
SCHEMBL8651840	0.70	1/20
SCHEMBL5351115	0.70	1/20
SCHEMBL5351119	0.70	1/20
SCHEMBL9128617	0.70	1/20
SCHEMBL4075867	0.69	1/20
SCHEMBL6699436	0.69	1/20
SCHEMBL5859444	0.69	1/20
SCHEMBL1098204	0.68	1/20
SCHEMBL1098207	0.68	1/20
SCHEMBL6699428	0.68	1/20
SCHEMBL2161281	0.66	1/20
SCHEMBL3042237	0.66	1/20
SCHEMBL609275	0.65	1/20
SCHEMBL1514760	0.65	1/20

Clinical trials — most relevant to DNASE1L3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Depletion of Serum Amyloid P Component to Enhance the Immune Response to DNA Vaccination	PHASE1/PHASE2	COMPLETED
Eltrombopag for People With Fanconi Anemia	PHASE2	ACTIVE_NOT_RECRUITING
Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100	PHASE1/PHASE2	COMPLETED
Adjuvant Oral Decitabine and Tetrahydrouridine With or Without Celecoxib in People Undergoing Pulmonary Metastasectomy	PHASE1	WITHDRAWN
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus	nan	ACTIVE_NOT_RECRUITING
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome	nan	COMPLETED
Genetics of Ehlers-Danlos Syndrome	nan	COMPLETED
Genetic Studies of X-linked Lymphoproliferative Disease	nan	COMPLETED
Genes in Predicting Outcome in Patients With Esophageal Cancer Treated With Cisplatin, Radiation Therapy, and Surgery	nan	COMPLETED
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia	nan	RECRUITING
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk	nan	NOT_YET_RECRUITING
Vascular Senescence and Atherosclerotic Plaque Vulnerability	nan	RECRUITING
SCOR in Neurobiology of Sleep--Intermediate Traits for Sleep Apnea	nan	COMPLETED
Genetics of Neonatal Encephalopathy and Related Disorders	nan	RECRUITING
Precision Genomics Medicine Biobank	nan	RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Biomarkers in Patients With Diffuse Large B-Cell Lymphoma Treated With Combination Chemotherapy With or Without Rituximab	nan	COMPLETED
Characterization of Sperm Population Following Different Selection Procedures	nan	UNKNOWN
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)	nan	COMPLETED
A Study Providing Genetic Testing to Find Those Who May Have Primary Ciliary Dyskinesia for Potential Clinical Trials	nan	ACTIVE_NOT_RECRUITING
Genetic Study of Age-Related Macular Degeneration	nan	COMPLETED
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease	nan	COMPLETED
Molecular Profile of the Evolution of Inclusion Body Myositis	nan	COMPLETED
Natural History of Autosomal Dominant Hearing Loss	nan	RECRUITING
Genetic of SportS Induced Endofibrotic Remodeling	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DNASE1L3 binder may also engage these)

Protein	Name	Similarity
O55070	—	1.000	O55070 →
O89107	—	1.000	O89107 →
O42446	—	0.988	O42446 →
Q9D7J6	—	0.985	Q9D7J6 →
Q9YGI5	—	0.985	Q9YGI5 →
Q2QDE6	—	0.983	Q2QDE6 →
Q2QDE7	—	0.981	Q2QDE7 →
P21704	—	0.976	P21704 →
O18998	—	0.974	O18998 →
P49183	—	0.974	P49183 →
P49184	—	0.974	P49184 →
Q2QDF1	—	0.972	Q2QDF1 →
Q14CN2	—	0.970	Q14CN2 →
P57748	—	0.970	P57748 →
Q8BG22	—	0.969	Q8BG22 →
O18767	—	0.968	O18767 →
Q05A56	—	0.968	Q05A56 →
Q811A3	—	0.968	Q811A3 →
Q10835	—	0.967	Q10835 →
Q9FF10	—	0.967	Q9FF10 →
ADAM10	Disintegrin and metalloproteinase domain-containing protein 10	0.967	landscape →
Q2M3T9	—	0.967	Q2M3T9 →
Q9CQF9	—	0.967	Q9CQF9 →
Q9Z218	—	0.967	Q9Z218 →
A6QP57	—	0.967	A6QP57 →
P07152	—	0.967	P07152 →
MMP20	Matrix metalloproteinase-20	0.967	landscape →
O77633	—	0.967	O77633 →
Q6Q473	—	0.967	Q6Q473 →
O55123	—	0.967	O55123 →