Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.84 |
| ▸ | MAPT | P10636 | 9/20 | 0.84 |
| ▸ | LMNA | P02545 | 6/20 | 0.84 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14132900 | 0.76 | MAPT (0.64) | KDM4EMAPTLMNAALOX12KMT2A | |
| SCHEMBL14133209 | 0.76 | LMNA (0.80) | KDM4EMAPTLMNAALOX12KMT2A | |
| SCHEMBL14146880 | 0.76 | MAPT (0.66) | KDM4EMAPTLMNAALOX12TDP1 | |
| SCHEMBL14133130 | 0.74 | MEN1 (0.69) | KDM4EMAPTLMNAALOX12TDP1 | |
| SCHEMBL14133357 | 0.74 | MEN1 (0.60) | MAPTLMNAKMT2AMEN1MAPK1 | |
| SCHEMBL14146882 | 0.74 | KDM4E (0.70) | KDM4EMAPTLMNAALOX12TDP1 | |
| SCHEMBL14133200 | 0.72 | LMNA (1.00) | KDM4EMAPTLMNAALOX12KMT2A | |
| SCHEMBL11255270 | 0.72 | KMT2A (0.73) | KDM4EMAPTLMNAALOX12TDP1 | |
| SCHEMBL14133199 | 0.72 | LMNA (0.85) | KDM4EMAPTLMNAALOX12KMT2A | |
| SCHEMBL14132615 | 0.72 | KDM4E (0.67) | KDM4EMAPTLMNAALOX12TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | NRAS, HRAS, KRAS | KDM4E 3950/4885MAPT 2885/4885LMNA 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.