Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.80 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.75 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195556 | 0.93 | ROCK2 (0.81) | ROCK2PKN2BRD4ABL1PRKCE | |
| SCHEMBL307285 | 0.89 | ROCK2 (1.00) | ROCK2PKN2CYP3A4CYP2C19 | |
| SCHEMBL307449 | 0.86 | ROCK2 (1.00) | ROCK2PKN2BRD4ABL1PRKCE | |
| SCHEMBL307684 | 0.85 | ROCK2 (0.81) | ROCK2PKN2BRD4PRKG1CYP3A4 | |
| SCHEMBL10196099 | 0.81 | ROCK2 (0.80) | ROCK2PKN2PRKCEPRKG1ITGB3 | |
| SCHEMBL10198173 | 0.80 | ROCK2 (0.61) | ROCK2PKN2JAK3CYP3A4CYP2C19 | |
| SCHEMBL307182 | 0.78 | ROCK2 (1.00) | ROCK2PKN2BRD4PRKG1CYP3A4 | |
| SCHEMBL306974 | 0.77 | ROCK2 (0.68) | ROCK2PKN2PRKG1CYP3A4 | |
| SCHEMBL307709 | 0.75 | ROCK2 (1.00) | ROCK2PKN2PRKCEPRKG1ITGB3 | |
| SCHEMBL306941 | 0.73 | ROCK2 (0.73) | ROCK2PKN2JAK3CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086047-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-17 | — | — | WO | disclosed |