Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15893906 | 0.89 | EPHX2 (0.41) | MEN1KMT2ALMNAEPHX2JAK2 | |
| SCHEMBL24501894 | 0.89 | EPHX2 (0.41) | MEN1KMT2ALMNAEPHX2JAK2 | |
| Hydrochloric Acid SCHEMBL5221768 | 0.87 | EPHX2 (0.40) | MEN1KMT2ALMNAEPHX2JAK2 | |
| Hydrochloric Acid SCHEMBL5221714 | 0.87 | EPHX2 (0.40) | MEN1KMT2ALMNAEPHX2JAK2 | |
| SCHEMBL31263468 | 0.81 | ALOX5AP (0.34) | TSHRALOX5APFEN1CA1CA2 | |
| SCHEMBL31263566 | 0.81 | ALOX5AP (0.34) | TSHRALOX5APFEN1CA1CA2 | |
| SCHEMBL13154397 | 0.79 | KMT2A (0.44) | MEN1KMT2ALMNAEPHX2TSHR | |
| SCHEMBL14136794 | 0.79 | TSHR (0.47) | MEN1KMT2ATSHR | |
| SCHEMBL969793 | 0.79 | TSHR (0.47) | MEN1KMT2ATSHR | |
| SCHEMBL8216463 | 0.79 | TSHR (0.47) | MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571881-A1 | PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | claimed |
| US-8329699-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | claimed |
| US-8329699-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |