SCHEMBL14136802

SCHEMBL14136802

CN(C)CCn1cnc(-c2cc3nccc(Oc4ccc(N5CCN(c6ccccc6)C5=O)cc4F)c3s2)c1

nearest known ligand 0.77

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.77
KDR P35968 15/20 0.77
MST1R Q04912 5/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14136810 0.89 MET (0.77) METKDRMST1R
SCHEMBL14136743 0.88 MET (0.77) METKDRMST1R
SCHEMBL5585871 0.87 MET (1.00) METKDRMST1R
SCHEMBL14136691 0.85 MET (0.77) METKDRMST1R
SCHEMBL14136788 0.84 MET (0.74) METKDRMST1R
SCHEMBL5585720 0.83 MET (0.90) METKDRMST1R
SCHEMBL306019 0.83 MET (0.61) METKDR
SCHEMBL14136731 0.82 MET (0.75) METKDRMST1R
SCHEMBL10272599 0.81 MET (0.59) METKDR
SCHEMBL306868 0.81 MET (0.59) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8329726-B2 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-12-11 US disclosed