Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.76 |
| ▸ | IRS1 | P35568 | 3/20 | 0.76 |
| ▸ | GAB1 | Q13480 | 3/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413850 | 0.88 | AKT1 (0.74) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL283324 | 0.87 | AKT1 (0.77) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL282664 | 0.86 | AKT1 (1.00) | AKT1IRS1GAB1 | |
| SCHEMBL1413996 | 0.84 | AKT1 (0.75) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL282264 | 0.83 | AKT1 (0.74) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL14864423 | 0.82 | AKT1 (0.66) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL14864432 | 0.81 | AKT1 (0.71) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL14864421 | 0.81 | AKT1 (0.70) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL283620 | 0.74 | AKT1 (0.83) | AKT1IRS1GAB1PKMHSD17B10 | |
| SCHEMBL283045 | 0.74 | AKT1 (1.00) | AKT1IRS1GAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477625-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | Phusis Therapeutics Inc. (US) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011032169-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| EP-2291349-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | The Board of Regents of The University of Texas System (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |