Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.75 |
| ▸ | GAB1 | Q13480 | 4/20 | 0.75 |
| ▸ | IRS1 | P35568 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282181 | 0.86 | AKT1 (0.75) | AKT1GAB1IRS1SMN1; SMN2PKM | |
| SCHEMBL282905 | 0.86 | AKT1 (1.00) | AKT1GAB1IRS1 | |
| SCHEMBL1413821 | 0.84 | AKT1 (0.76) | AKT1GAB1IRS1ALDH1A1PKM | |
| SCHEMBL282840 | 0.82 | AKT1 (0.67) | AKT1GAB1IRS1ALDH1A1LMNA | |
| SCHEMBL14864429 | 0.81 | AKT1 (0.65) | AKT1GAB1IRS1ALDH1A1LMNA | |
| SCHEMBL14864424 | 0.81 | AKT1 (0.69) | AKT1GAB1IRS1ALDH1A1LMNA | |
| SCHEMBL1413850 | 0.80 | AKT1 (0.74) | AKT1GAB1IRS1ALDH1A1PKM | |
| SCHEMBL20657476 | 0.72 | GHSR (0.55) | ALDH1A1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL11334918 | 0.71 | LMNA (0.63) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22438952 | 0.71 | LMNA (0.63) | ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477625-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | Phusis Therapeutics Inc. (US) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011032169-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| EP-2291349-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | The Board of Regents of The University of Texas System (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |