Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14138510 | 0.91 | BRAF (0.55) | BRAFRAF1 | |
| SCHEMBL14138585 | 0.82 | BRAF (0.59) | BRAFRAF1 | |
| SCHEMBL3590796 | 0.81 | BRAF (0.85) | BRAFRAF1 | |
| SCHEMBL14138570 | 0.74 | BRAF (0.66) | BRAFRAF1 | |
| SCHEMBL14138678 | 0.73 | BRAF (0.41) | BRAFRAF1 | |
| SCHEMBL3587726 | 0.73 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL14138580 | 0.73 | CACNA1H (0.43) | BRAF | |
| SCHEMBL14138869 | 0.73 | BRAF (0.65) | BRAFRAF1 | |
| SCHEMBL3594949 | 0.72 | BRAF (0.79) | BRAFRAF1 | |
| SCHEMBL14138684 | 0.72 | BRAF (0.66) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |