Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585446 | 0.79 | BRAF (0.63) | BRAFRAF1PKM | |
| SCHEMBL14138580 | 0.77 | CACNA1H (0.43) | BRAFPKM | |
| SCHEMBL3588121 | 0.75 | BRAF (0.66) | BRAFRAF1 | |
| SCHEMBL14138561 | 0.73 | BRAF (0.58) | BRAFRAF1 | |
| SCHEMBL14138705 | 0.73 | SCD (0.40) | BRAF | |
| SCHEMBL14138603 | 0.73 | PKM (0.37) | BRAFRAF1PKM | |
| SCHEMBL14138708 | 0.71 | PKM (0.38) | BRAFPKM | |
| SCHEMBL14138703 | 0.70 | ALDH1A1 (0.40) | BRAFPKM | |
| SCHEMBL14138535 | 0.68 | PRKCI (0.38) | BRAFPKM | |
| SCHEMBL14138527 | 0.67 | PKM (0.36) | BRAFPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |