Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALK1 | P51570 | 16/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587161 | 0.76 | BRAF (0.56) | BRAF | |
| SCHEMBL14138693 | 0.66 | BRAF (0.37) | BRAF | |
| SCHEMBL880267 | 0.64 | RAB9A (0.46) | GALK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15359732 | 0.63 | RAB9A (0.40) | GALK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14138854 | 0.63 | BRAF (0.37) | BRAF | |
| SCHEMBL14138671 | 0.63 | BRAF (0.36) | BRAF | |
| SCHEMBL14138556 | 0.61 | BRAF (0.73) | BRAF | |
| SCHEMBL14138582 | 0.60 | BRAF (0.45) | BRAF | |
| SCHEMBL14138586 | 0.60 | BRAF (0.51) | BRAF | |
| SCHEMBL14138806 | 0.58 | BRAF (0.47) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |